Relationship between ankle-brachial index and urinary albumin to creatinine ratio in patients with type 2 diabetes mellitus

Objective To investigate the relationship between ankle-brachial index(ABI) and urinary albumin to creatinine ratio(UACR) in patients with type 2 diabetes mellitus.Methods From January 2009 to January 2011,a total of 469 type 2 diabetic patients were enrolled.The ABI,UACR and other related indexes were measured.Thirty-eight healthy subjects served as controls.Results In all 469 patients,the prevalence of urinary protein was 62.7%;the prevalence of abnormal ABI 42.6%.Prevalence of abnormal ABI was 41.4%,23.2% and 14.9% in the clinical,micro-and normal albuminuria.Prevalence of urinary protein was 45.2%,31.5% and 22.7% in the patients with ABI≤0.9,ABI1.3,and ABI 0.9-1.3.Multiple variables analysis showed that the influence factors for the occurrence of lower extremity arterial lesions in diabetes mellitus patients were age,blood pressure,fasting plasma glucose,total cholesterol,low density lipoprotein-cholesterol,HbA1C,UACR and GFR(P0.05).Conclusions The diabetes mellitus patients with abnormality of ABI usually have a high prevalence of increased ACR.ABI is also affected by age,blood glucose,blood lipids,and blood pressure.