Additive effect of bunazosin on intraocular pressure when topically added to treatment with latanoprost in patients with glaucoma

Abstract Purpose: To investigate whether an α-1 blocker, bunazosin, has an additive effect on lowering intraocular pressure (IOP) when topically added to latanoprost treatment in patients with glaucoma. Methods: Bunazosin twice a day was added topically to the treatment for 12 patients with glaucoma who had been instilling latanoprost once a day for more than 1 month. IOP was measured and adverse events were checked 2, 4 and 8 weeks after the addition of bunazosin to their treatment. Results: One of the 12 patients dropped out in the course of the study. Therefore, 11 patients were included for the analysis of IOP, and 12 for the analysis of adverse events. IOPs were decreased significantly ( P  = .008, Wilcoxon signed rank test) from 18.2±3.4 mm Hg to 16.6±3.5 mm Hg 8 weeks after the addition of bunazosin. Adverse events were seen in 5 of the 12 patients. Conclusion: Bunazosin has an additive effect on lowering IOP when topically added to latanoprost treatment in glaucoma patients.