Update on the effects of ryanodine receptor 2 phosphorylation on the pathogenesis of catecholaminergic polymorphic ventricular tachycardia

S.-Y. Li,T T Lyu,Ping Zhang

Update on the effects of ryanodine receptor 2 phosphorylation on the pathogenesis of catecholaminergic polymorphic ventricular tachycardia

2021

S.-Y. Li
T T Lyu
Ping Zhang

兰尼碱受体2（RyR2）是调节心肌细胞兴奋收缩偶联的重要离子通道蛋白，RyR2的磷酸化在生理条件下调节心肌细胞肌浆网Ca2+储存和释放过程。儿茶酚胺敏感性多形性室性心动过速（CPVT）是一种遗传性离子通道疾病，RyR2基因突变是其最常见的突变形式。RyR2磷酸化异常引发的钙泄漏是CPVT发作的重要病理生理机制，不同的RyR2突变对RyR2磷酸化的影响不同。本文综述了RyR2磷酸化异常在CPVT中的病理作用。.

Keywords:

Ryanodine receptor 2
Phosphorylation
Catecholaminergic polymorphic ventricular tachycardia
Pharmacology
Medicine
Pathogenesis

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