Celiac disease: Evaluation of serological course in two series of patients diagnosed with or without small-bowel biopsies

s / Digestive and Liver Disease 47S (2015) e237–e276 e267 Results: 51 out of 468 (11%) patients were diagnosed without a duodenal biopsy (Group 1; median age 2.1 years) and matched to 92 patients diagnosed with a biopsy (Group 2; median age 2.4 years). At the end of follow-up (median: 1.9 years) the two groups resulted statistically comparable for clinical and nutritional status, serum anti-transglutaminase IgA antibodies titres, quality of life, adherence to GFD and number of supplementary post-diagnosis medical consultations. Conclusions: The diagnosis of CD can be safely performedwithout a duodenal biopsy at least in 11% of cases. At least during a medium-term follow-up, this approach has no negative consequence on clinical remission, adherence to diet, and quality of life of children. http://dx.doi.org/10.1016/j.dld.2015.07.129