Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

Objectives Diabetic neuropathy (DNP) is a widespread and debilitating complication with complex pathophysiology that is caused by neuronal dysfunction in diabetic patients. Conventional therapeutics for DNP are quite challenging due to their serious adverse effects. Hence, there is a need to investigate novel effective and safe options. The novelty of the present study was to provide available therapeutic approaches, emerging molecular mechanisms, signaling pathways and future directions of DNP as well as polyphenols’ effect, which accordingly, give new insights for paving the way for novel treatments in DNP.