Treatment with Aclasta in postmenopausal osteoporosis rats

Objective:To study the treating effect of Aclasta on rat postmenopausal osteoporosis.Methods:Sixteen rats models of postmenopausal osteoporosis were established by removing two ovaries of the rats.They were randomly divided into group A and B,with 8 rats each.The rats in group A were administrated with Aclasta,and the rats in group B were not treated.Eight normal female rats were chosen as the controls(group C).Bone density,serum osteocalcin,osteprotegerin and osteprotegerin ligand were assessed after 12 weeks.Results:The bone density in group A was significantly higher than that in group B(P 0.01),while the serum osteocalcin level and the ratio of osteprotegerin ligand/osteprotegerin were significantly decreased in group A(P 0.01).Conclusion:Application of Aclasta has a good therapeutic effect on rat postmenopausal osteoporosis,which may be related to decreasing serum osteocalcin level and the ratio of osteprotegerin ligand/osteprotegerin.