Online monitoring of cerebral hemodynamics during hemodialysis

Abstract Background: Several factors, including anemia, diabetes, and hypertension, potentially could disturb the cerebral autoregulation mechanism in hemodialysis (HD) patients. This study examined the effect of hemodynamic and rheological changes on mean cerebral blood flow (CBF) velocity (MV) during HD. Methods: Continuous online monitoring of MV and pulsatility index in the middle cerebral artery were performed in 18 HD patients by transcranial Doppler ultrasound during the entire HD period (range, 3 to 4 hours). In addition, blood pressure, hematocrit (Hct), and relative decrease in blood volume were continuously monitored. Blood samples were obtained at the beginning and end of HD to measure hemorheological variables. Results: After HD, Hct increased significantly from 33.6% ± 5.9% to 41.4% ± 5.7% ( P P P P Conclusion: Results of this study suggest that CBF does not appear to be diminished significantly during HD. Am J Kidney Dis 40:996-1004. © 2002 by the National Kidney Foundation, Inc.