SAT0567 The leading risk factors for developing intensive pain syndrome in the knee joints in patients with ostheoartritis

Background Intensive pain is one of key predictors of OA progression, although it remains unclear which key factors are responsible for the development of intensive pain. Objectives To study the risk factors for developing intensive knee pain in OA pts in a multicenter prospective study. Methods A prospective 5 year study included 185 female-patients from 6 RF territorial entities aged 40–75 y. with confirmed knee OA (ACR criteria), stages I-III (Kellgren J.-Lawrence J), who signed an informed consent. Mean age was 59±8,1 y., the age at knee pain onset was 49±8,7 y., and average OA duration was 11±8,4 y. Individual annual medical file included patient’s anthropometric parameters, case history, clinical examination findings, evaluation of knee pain intensity by VAS, WOMAC scale, the knee joint status, comorbidities and therapeutic modalities used during the follow up period. Instrumental diagnostic methods included plain radiography of knee joints, dual energy X-ray absorptiometry (DEXA) of the lumbar spine, femoral neck and of subchondral bone of the hip and tibia, ultrasonography (US) and MRI examination of knee joints. Stage II of knee OA was documented in 135 (73%) out of 185 pts, and stage III – in 50 (27%). Statistica10.0 and SPSS 15.0 packages were used for statistical analysis. Results Based on pain intensity pts were divided into two groups: Group I – pts with more intensive pain (>70 mm VAS) – 16,8%, and Group II – pts with less intensive knee pain ( Conclusions In a prospective multicenter study, using comprehensive instrumental modalities (knee radiography, ultrasonography, MRI and BMD of peripheral bones and subchondral hip and tibia) it has been demonstrated that intensive knee pain (>70 mm VAS) is caused by excessive functional impairment, presence of knee varus deformity, Heberden’s nodes, OA in parents, and cartilage destruction in the medial tibial compartment. Disclosure of Interest None declared