Asymmetric synthesis of β-amino ketones by using cinchona alkaloid-based chiral phase transfer catalysts
2018
A highly enantioselective nucleophilic addition of ketones to imines catalyzed by chiral phase-transfer catalysts (N-quaternised cinchona alkaloid ammonium salts) has been developed, and the process affords the Mannich reaction products with tertiary stereocenters in good to high yields (up to 95%) with excellent enantioselectivities (up to 97% ee).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
64
References
3
Citations
NaN
KQI