Excitation of Enteric Neurons by Supernatants of Colonic Biopsies From Irritable Bowel Syndrome Patients (IBS) is Linked to Visceral Sensitivity

but DAT and NET contribute to 5-HT clearance. As the animals mature beyond 3 weeks, SERT function increases while DAT function declines. NET and SERT both contribute to 5-HT clearance in the mucosa of 6 week old guinea pigs. These data indicate that there are redundant transport mechanisms for 5-HT clearance in the gut mucosa. Monoamine transport inhibitors used to treat behavioral problems in pediatric patients could have unanticipated effects on gut function. (Supported by DK57039, DK082967, HD05197)