Epithelial to Mesenchymal Transition in Ovarian Cancer Cell

Abstract Epithelial ovarian cancer is the most lethal gynecologic malignancy with the majority of cases being diagnosed after the disease has become metastatic according to the report by Obstetrics and Gynecology, Duke University Medical Center USA, 2008. Consequently, genetic and epigenetic changes that disturb motility are likely to be important for the pathogenesis of ovarian cancer. Although ovarian cancer can be cured in up to 90% of cases while still confined to the ovary, approximately 70% are diagnosed after the occurrence of peritoneal dissemination, when the cure rate reduces to less than 30% according to recent studies by Global Cancer Statistic, CA Cancer 2011. Recent reports have shown 25% of most cancerous cells within tumors have the features of cancer stem cells (CSCs). CSCs have been identified on the basis of their ability to self-renew and to have the capacity to differentiate into cancer cells and also form tumors in animal model. We already demonstrated that the majority of cells of o...