ASYMMETRIC DIMETHYLARGININE IN HYPER- CHOLESTEROLEMIC PATIENTS

Background: In the medical literature, data on the levels of ADMA in patients with HH is scarce. Aim: To study the level of asymmetric dimethylarginine in asymptomatic, marked, never-treated hypercholesterolemia. Methods: 30 asymptomatic patients with marked, never-treated hypercholesterolemia and 30 controls were evaluated. The plasma level of asymmetric dimethylarginine (ADMA) was tested by ELISA method. Results: A statistically significant difference was found between patients and controls, regarding all tested parameters, including lipid and non-lipid marker asymmetric dimethylarginine. (p<0.001) Conclusion: It is concluded that asymptomatic, marked, never-treated HH is associated with elevated levels of ADMA, and this is related to the proportional increase in total cholesterol.