Applied Genomics and Public Health Cancer Genomics

Abstract Cancer is one of the leading causes of death and is a growing public health menace worldwide. Cancer has long been established as a disease originating due to genomic overburden of mutations leading to a cascade of tumor-promoting events. Even with the advent of new therapeutic approaches as the standard of care for several cancers, we still lag in predicting patient’s response to these therapies or the duration of these responses. To sufficiently understand the contribution of various genetic aberrations and different regulatory pathways, genomics and epigenomics are taking an increasingly pivotal position in the era of precision medicine. In this chapter, we explain how various tools of genomics and integrated bioinformatics analysis are being used to address many of the crucial questions in cancer medicine.