Intravascular lymphoma of lymphoid: a case report and literature review

To investigate the clinical and pathological features of IVL. A case of IVL of inguinal lymph node was studied with clinical findings, histopathology and immunohistochemisty as well as literature review. A case of 31-year-old man presented with unknown fever and inertia of both low extremities and weight loss for 50 days, one of the right inguinal lymph node was found, muscle power of both low extremities was II-Ⅲ grade, liver was light enlargement, and with elevation of serum LDH、COP、GTP and ESR, leukemia was ruled out by peripheral blood and bone marrow aspirate smears, all sorts of pathogen and tumor associated antigen were negative. Intravascular T-cell lymphoma was confirmed by biopsy and immunohistochemieal studies, followed by combination chemotherapy yielding complete response, and now this patient is being followed-up. IVL is an unusual form of non-Hodgkin lymphoma characterized by intravascular proliferation of atypical lymphoid cells in multiple organs, with a predilection for nervous system and skin involvement, Lymphod involvement is quite rare, Mainly B-cell immurmphenotypes and rare T-cell, diagnosis is dependent on biopsy, often favourable responses to chemotherapy, but prognosis is generally poor, the pathogenesis remains unknown.