The analysis of human papillomavirus infection in lip squamous cell carcinoma patients

Objective To analyze the infection of human papillomavirus in lip squamous cell carcinoma patients.Methods The pathological samples of 9 clinical diagnosed lip cancer patients were collected.Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.Results In the 9 cases,1 was positive for HPV16 gene and 7 were positive for HPV16/18 E6 protein expression.The total positive rate was about 8/9.Conclusion The high HPV infection rate in lip cancer patients in the study indicated indirectly that the importance of the direct contact to the infection of HPV what was the basis for pathogenesis of the lip squamous cell carcinoma. Key words: Lip neoplasms; Carcinoma,squamous cell; Papillomavirus,human