Infection Feature and Drug Resistance of Bacteria of Inferior Respiratory Tract in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Guiyang of China

Objective To investigate the infective bacteria of inferior respiratory tract by analyzing sputum and secretion from inferior respiratory tract in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) in Guiyang of China,and to provide evidence for clinical therapy.Methods Sputum and secretion of inferior respiratory tract of 254 patients with AECOPD admitted in our hospital from 1 April 2009 to 30 April 2010 in Guiyang were cultured and drug sensitivity tests were conducted,with one or more strains of bacteria being cultured.Results Positive sputum and secretion of inferior respiratory tract culture were found in 215(84.65%) patients with AECOPD,and 516 strains of pathogenic bacteria were cultured.Among these bacteria,the six main pathogenic bacteria were 305(59.11%) strains of moraxella catarrhalis,108(20.93%) strains of streptococus viridans,22(4.26%) strains escherichia coli,14(2.71%) strains of enteroaerogen,14(2.71%) strains of klebsie pneumoniae and 11(2.13%) strains of hafnia alvei.There were single infective bacteria in 154 patients with AECOPD and mixing infective bacteria in 61 patients with AECOPD.Single infective bacteria were the mainly influence factors for the severity of AECOPD.Single infective bacteria and mixing infective bacteria both showed linear regression correlation with the severity of AECOPD.The same bacterial isolates were founded many times in sputum cultures,but the drug resistances of these outcomes were not the same in 60 patients with AECOPD.Six main types of pathogenic bacteria had more drug resistance(moraxella catarrhalis et al) to penicillin,ampicillin,erythromycin,ofloxacin and ciprofloxacin.Most of the gram-negative bacillus had low drug resistance to cephalosporins.The positive sputum germiculture was positively correlated with the severity of heart function of corpulmonale.Conclusion The moraxella catarrhalis and treptococus viridans are the main pathogenic bacteria in inferior respiratory tract in patients with AECOPD in Guiyang of China.The streptococcus pneumoniae and haemmophilus influenzae are not the common pathogenic bacteria.With the increasing severity of AECOPD,there are more opportunities for mixing infective bacteria.It is important to rationally use antibacterials,especially combined use of antibacterials.