Complete radiological response to first-line regorafenib in a patient with abdominal relapse of BRAF V600E mutated GIST:

Up to 13% of KIT and PDGFRA wild-type (WT) gastrointestinal stromal tumours (GIST) harbour a BRAF mutation, mostly involving the exon 15 V600E hot spot. Even if BRAF mutation is recognized as drugg...