Health-related quality of life in patients with primary Sjögren's syndrome: relationship with serum levels of proinflammatory cytokines

Objective: A cross-sectional study of 30 patients with primary Sjogren's syndrome (pSS) was performed to analyse the health-related quality of life and its relationship with serum levels of macrophage- and lymphocyte-derived cytokines.Patients and methods: Health-related quality of life was evaluated using the 36-item Short Form Health Survey (SF-36). Serum levels of interleukin (IL)-1β, IL-6, IL-10, tumour necrosis factor (TNF)-α, and gamma-interferon (γ-INF) were analysed by a sandwich immunoassay-based protein array system.Results: Each of the eight scales of the SF-36 evaluating quality of life, as well as the physical composite score (PCS) and the mental composite score (MCS), showed a decrease in pSS patients. Similarly, patients with pSS showed significantly increased concentrations of each of the five cytokines analysed, when compared with the healthy control group (n = 20). In pSS patients, a significant negative correlation was detected between serum levels of IL-6 and the PCS of the SF-36. Thos...