IDDF2019-ABS-0326 Evaluation of the effects of the hydroalcoholic extract of liv.52 DS on paracetamol induced liver toxicity and oxidative stress in rats

Background Oxidative stress induced by toxicants is known to cause various complications in the liver. Herbal drug such as Liv.52 is found to have a hepatoprotective effect. However, the biochemical mechanism involved in the Liv.52 DS mediated protection against toxicity is not well elucidated using suitable in vivo models. Paracetamol causes oxidative stress and dysfunction of the liver. This study was undertaken to evaluate the effects of the hydroalcoholic extract of Liv.52 DS on some biochemical and histopathological parameters of liver tissue in against paracetamol-induced hepatic damage in rats. Methods Wistar rats were orally administered with 2 g/kg body weight Paracetamol. Vehicle (distilled water) and silymarin (50 mg/kg body weight) was used as the negative and positive control groups, respectively. Paracetamol-administered groups were treated with Liv 52 DS extract (100, 200, and 400 mg/kg). After 15 days of treatment, the blood specimens and liver samples were examined. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and lipid peroxides were tested, and phytochemical tests were also performed. Results In Paracetamol-treated group, the levels of serum urea, high-density lipoprotein (HDL), and liver superoxide dismutase (SOD), catalase (CAT), and vitamin C significantly decreased (p Conclusions The present study suggests that Liv. 52 DS extract possesses hepatoprotective activity. It could be an effective and promising preventive agent against Paracetamol-induced hepatotoxicity.