3D NUMERICAL STUDY OF CELL DEFORMATION AND MIGRATION IN A FLOW CHAMBER

In recent years, the physiological phenomena of cell displacement and deformation in blood vessels have gradually become an important topic in the field of biomechanics, and also have important theoretical significance and application value in clinical medicine. To study the migration and deformation of blood cell, the influence of elastic modulus on its behavior, and the effect of deformation on its migration. A numerical simulation of a single cell displacement and deformation in a flow chamber was conducted in the present study using a computer program based on the fluid–solid coupling. The displacement and deformation of the cells with different elastic modulus as well as the influence of deformation on the movement of the cell were investigated. The results showed that the cell with greater elastic modulus had a smaller deformation in the direction of gravity and fluid velocity. The deformation of the cell had obvious effect on the displacement in the direction of gravity. The smaller the deformation of the cell in the direction of gravity was, the higher the cell could jump. The three-dimensional numerical calculation method adopted in this paper and the results obtained can provide a reference for the study of the cell mechanic behavior in the vessels.