1228 Environmental Tobacco Smoke Exposure, Pregnancy Outcomes and Children's Health

Aim: The aim of the study was to analyze the influence of environmental tobacco smoke exposure on pregnancy outcome and children's health. Material and Methods: The study population consisted of pregnant women and their children followed up to two years of life. Pregnant women were interviewed three times during pregnancy. From all women included into the study the saliva sample was collected. Assessment of child ETS exposure within two years after birth was based on questionnaires, confirmed by biochemical verification of cotinine level in child urine. Cotinine level in biological samples was analyzed using Liquid Chromatography with Tandem Mass Spectrometry. Pregnancy outcomes were noticed by neonatologist. The children's health focused on anthropometry indicators and the incidences of respiratory infections and allergy was performed by pediatricians during the first and second year of life. Results: For the lower cotinine levels in saliva (up to 10 ng/ml) we observed increasing trend in birth weight, head and chest circumference with the increasing level of cotinine (p trend < 0.05). For the cotinine level higher than 10 ng/ml we noticed decreasing trend for birthweight, head and chest circumference as the level of this biomarker increased. The newborn length decreased with the increasing cotinine level in saliva (p trend < 0.001). There were no statistically significant associations between ETS exposure and anthropometric measurements within first two years of life. Such exposure increases the risk of pneumonia but the results were not statistically significant. Conclusions: All effort should be taken to eliminate the child ETS exposure.