The use of whole exome sequencing and murine patient derived xenografts as a method of chemosensitivity testing in sarcoma
2018
Background
Soft tissue and bone sarcoma represent a broad spectrum of different pathology and genetic variance. Current chemotherapy regimens are derived from randomised trials and represent empirical treatment. Chemosensitivity testing and whole exome sequencing (WES) may offer personalized chemotherapy treatment based on genetic mutations.
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