Abstract 12923: The Sustained Benefit of Short Term Treatment With Colchicine After Acute Myocardial Infarction

Background: In acute myocardial infarction (MI), acute inflammation and NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome are involved in cardiac damage, remodeling, and developing heart failure (HF). Several studies have reported that colchicine attenuated the infarct size and inflammation in MI. However, the sustained benefit of colchicine administration after MI on survival and cardiac function is unknown. We hypothesized that short-term treatment with colchicine could inhibit the cardiac inflammation and NLRP3 inflammasome, and improve survival and cardiac function during recovery phase of MI. Methods: Mice were induced MI by permanent ligation of the left anterior descending coronary artery. Mice randomly received 0.1 mg/kg/day colchicine or saline (control) orally from one hour to 7 days after MI. Results: Colchicine significantly improved survival rate compared with control at 4 weeks after MI (colchicine, n=48: 89.6% vs. vehicle, n=51: 70.6%, P<0.01). Colchicine signi...