Extended duration of direct hemoperfusion with polymyxin B-immobilized fiber column improves hemodynamics in patients with septic shock

Endotoxin adsorption therapy by direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) has been widely used in patients with septic shock in Japan. Many Japanese doctors use each PMX cartridge only for 2 hours; however, the mechanisms and optimal duration of PMX treatment remain unclear. We have performed PMX-DHP for longer than 2 hours to confirm that an extended duration of PMX-DHP for patients with septic shock would give significant improvements of hemodynamics.