Autologous Hematologic Recovery from Aplastic Anemia following High Dose Cyclophosphamide and HLA-Matched Allogeneic Bone Marrow Transplantation

A 17-year-old woman with severe aplastic anemia was treated with high-dose cyclophosphamide followed by infusion of bone marrow cells from her HLA-identical, ABO-incompatible brother. The marrow graft failed to take. Subsequently, the patient revealed an autologous marrow reconstitution leading to a near-complete hematologic recovery which is now persisting for over 20 months.