Abstract 16738: International Variation in Management and Clinical Outcome of Patients With Type 2 Diabetes and Heart Failure: Insights From TECOS

Introduction: We evaluated international variations in management and clinical outcome for patients with type 2 diabetes and heart failure (HF) by region in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). Methods: Among 14,671 TECOS patients, those with a baseline history of HF for whom documented baseline ejection fraction (EF) was available (N=1591) were categorized by geographic region. We examined regional variation in baseline characteristics and clinical outcome (death/HF hospitalization) using adjusted Cox models with North America as the reference cohort. Results: Of 1591 (10.8%) patients with HF and documented EF, the majority originated from Eastern Europe (Eastern Europe [N=847; 21% of enrolled in region], North America [N=237; 9% of enrolled in region], Western Europe [N=191; 9% of enrolled in region], Asia Pacific [N=162; 4% of enrolled in region], and Latin America [N=154; 10% of enrolled in region]). Most patients had EF≥40% (N=1267, 79.6%). Patients with EF<40% overa...