099 History of breast cancer in women with acute myocardial infarction. Data from the RICO survey

Background Breast Cancer (BC) is the most frequent cancer, whereas CV diseases such as myocardial infarction (MI) are the leading cause of death. BC and MI share common major risk factors such as obesity. We aimed to analyse the characteristics of women with a history of BC in the setting of acute MI. Patients and methods Among the 2087 consecutive women included between 01/01/2001 and 31/12/2009 in the French regional RICO survey database, 73 (3%) had a history of BC. Each woman with prior BC (n = 73) was matched, with respect to age, with 5 women without prior BC (n = 365). Results Women with prior BC were 74 (65–80) year old. Time from BC diagnosis to acute MI was 10 (3–16) years. Most BC had been treated by surgery and/or radiation therapy, and 37% had also received hormone therapy. CV risk factors (smoking, obesity), type of MI, acute management and in-hospital complications were similar for the 2 groups. Chronic statin use and admission blood lipids were also identical for the 2 groups. However, median admission CRP levels were lower in women with a history of BC (1.0(1.0–9.8) vs. 5.6 (2.8–13.6) mg/l, respectively, p  Conclusions In women currently admitted for acute MI, a non-negligible proportion had prior BC. Women with prior BC had a similar risk profile and lipid levels to those in women without prior BC. However, they were characterized by a lower level of inflammation and smaller infarct size than their counterparts without BC. Further investigations are ongoing to determine whether hormone therapy such as oestrogen receptor modulators could account for the observed effects in this population.