THU0185 THE FIRST REPORT OF SIGNIFICANTLY IMPROVEMENT OF NT-PROBNP LEVEL IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH TOFACITINIB DURING 12-MONTH FOLLOW-UP

Background The amino-terminal fragment of the B-type natriuretic peptide prohormone (NT-proBNP) is a marker for functional cardiac impairment and is increased in heart disease with or without symptoms of congestive heart failure (CHF)1. Objectives To prospectively investigate the effect of tofacitinib (TOFA) on the levels of NT-proBNP, as a predictor of CHF in patients (pt) with active rheumatoid arthritis (RA). Methods Twenty six RA pt (median age 54 [40;62] years, 81% female, disease duration 44[24;63,0] month (m), moderate to high activity (DAS28-5.1[4.6;6.1], SDAI–27(22;35)), positive for ACCP (73%)/RF (77%), who were non-responders to MTX at least 15 mg/week and/or other synthetic DMARDs and bDMARDs) free of clinical overt cardiovascular disease were treated with TOFA and followed for 12 m. TOFA therapy was started in all pt in dose 5 mg BID per os with dose escalation to 10 mg BID in 8 (31%) pt. TOFA used in combination with MTX in 24 (92%) pt, leflunomide in 1 (4%). Low-dose oral corticosteroids ( Results The NT-proBNP level was significantly higher in RA pt than in the control group (median 62.2(26.9-101.7) pg/mL vs 44.0 (34.0-54.3) pg/mL, p Conclusion TOFA decreased the NT-proBNP level in patients with RA without clinical overt cardiovascular disease and CHF. TOFA may have a cardioprotective effect in those with active RA. Reference [1] Breunig M., Kleinert S., Lehmann S. et al. Simple screening tools predict death and cardiovascular events in patients with rheumatic disease. Scand J Rheumatol2018;47(2):102-109. doi: 10.1080/03009742.2017.1337924. Disclosure of Interests Diana Novikova: None declared, Irina Kirillova: None declared, Eugenia Markelova: None declared, Helen Udachkina: None declared, Helen Gerasimova: None declared, Helen Luchihina Speakers bureau: Pfizer, Abbvie, Biocad, Dmitriy Karateev: None declared, Natalia Demidova: None declared, Anna Misiyuk: None declared, Maria Cherkasova: None declared, Tatiana Popkova: None declared