122 Evaluation of urine protein/creatinine ratio in hypertensive disorders during pregnancy

Introduction Assessment of proteinuria is essential to diagnose preeclampsia; it can be detected in spot urine sample or 24-hour urine collection. It has been shown that urine protein to creatinine (P/C) ratio seems to be highly predictive for detection of proteinuria in preeclampsia (PE). Objectives Evaluation of P/C ratio in normal pregnancy, and pregnant women with chronic hypertension (CH) and with PE. Methods P/C ratio was measured in 24 normal pregnant women, 14 with PE and 97 with CH. Proteinuria was detected by automated pyrogallol method and creatininuria by alkaline picrate method. Results Mean age of control group was 26 years, of PE group, 26 years and of CH group 34 years. P/C ratio was undetected in the control group, it was elevated in 5.2% of the CH group and in 100% of the PE group, also confirmed with 24-hour urine collection. Serum creatinine was elevated in 19.6% of the CH group and 42.8% of the PE group. Conclusions P/C ratio may be a good predictor of PE and it could be used as an alternative test to detect proteinuria in pregnant women, because it is faster and it is not influenced by serum creatinine concentration. Proteinuria should be evaluated during the prenatal care of CH women allowing early detection of incipient nephropathy. Fapesp n° 2014/00213-7. Renal evaluation in preeclampsia group.