Effects of Guipi Decoction on Hypothalamus-Hypophysis-Thyroid Hormones of Insomnia Patients with Heart and Spleen Deficiency

Objective:To study the effects of Guipi decoction on hypothalamus-hypophysis-thyroid hormones of insomnia patients with heart and spleen deficiency.Methods:80 patients were randomly divided into two groups,50 in the treatment group and 30 in the control group.The treatment group took Guipi decoction,100mL each time,twice a day.The control group took 1mg estazolam tablet orally once a day before sleeping at night.The treatment course for both groups was eight weeks.Besides,a normal control group of 30 healthy subjects from medical examination of the same hospital was set up.The curative effect was evaluated by scales of PSQI and levels of serum T3,T4,TSH and TRH through radio immunoassay.Results:The levels of serum T3,T4,TSH and TRH of insomnia patients with heart and spleen deficiency were obviously lower than those of the healthy subjects(P0.05).Through the treatment of Guipi decoction,the PSQI scales of the treatment group were more significantly improved than those of the control group(P0.05).The levels of serum T3,T4,TSH and TRH were more apparently increased than those of the control group(P0.05).However,the levels of serum T3 and T4 of the treatment group showed no difference with those of the healthy group(P0.05).Conclusion:The hypofunction of hypothalamus-hypophysis-thyroid hormones can be observed in the insomnia patients with heart and spleen deficiency.Guipi decoction makes more differences in the improvement of the levels of PSQI and serum T3,T4,TSH and TRH.