Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis

Daisuke Ito,Atsushi Hashizume,Yasuhiro Hijikata,Shinichiro Yamada,Yohei Iguchi,Madoka Iida,Yoshiyuki Kishimoto,Hideyuki Moriyoshi,Akihiro Hirakawa,Masahisa Katsuno

Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis

2019

Daisuke Ito
Atsushi Hashizume
Yasuhiro Hijikata
Shinichiro Yamada
Yohei Iguchi
Madoka Iida
Yoshiyuki Kishimoto
Hideyuki Moriyoshi
Akihiro Hirakawa
Masahisa Katsuno

Objective To assess the changes of muscle-related biomarkers at the early stage of amyotrophic lateral sclerosis, and to confirm these findings in an experimental animal model.

Keywords:

Animal model
Internal medicine
Creatine kinase
Diabetes mellitus
Elevated serum creatine kinase
Endocrinology
Biomarker (medicine)
Physical therapy
Medicine
Amyotrophic lateral sclerosis
Atrophy
Muscle Denervation
SOD1
Denervation
Gastrocnemius muscle
Creatinine

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