METALLO-BETA-LACTAMASES PRODUCING ACINETOBACTER BAUMANNII: A MAJOR THREAT TO PATIENTS HEALTH

Acinetobacter baumannii is common gram-negative non-fermenter opportunistic bacteria associated with nosocomial infections, especially among hospitalized patients. In this study, PubMed, Scopus and Google Scholar were searched using the following keywords: “Acinetobacter baumannii,” “metallo-β-lactamases,” “Iran”. Of Ninty-eight articles, twenty-eight were eligible to be included in our systematic review. These studies were carried out in Tehran, Tabriz, Arak, Hamadan and Mashhad city in Iran. SPM-producing A. baumannii reported of Tehran, IMP-producing A. baumannii reported of Tehran, Tabriz and Arak and VIM-producing A. baumannii reported of Tehran, Tabriz, Hamadan and Mashhad in Iran. Among MBL genes, blaVIM is more than other genes in Iran. The prevalence of s-lactamase-producing isolates, and their isolation from life-threatening infections, is increasing worldwide at an alarming rate.