MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

Abdellah Mansouri,Arige Tarhuni,Isabelle Larosche,Florence Reyl-Desmars,Christine Demeilliers,Françoise Degoul,Pierre Nahon,Angela Sutton,Richard Moreau,Bernard Fromenty,Dominique Pessayre

MnSOD overexpression prevents liver mitochondrial DNA depletion after an alcohol binge but worsens this effect after prolonged alcohol consumption in mice.

2010

Abdellah Mansouri
Arige Tarhuni
Isabelle Larosche
Florence Reyl-Desmars
Christine Demeilliers
Françoise Degoul
Pierre Nahon
Angela Sutton
Richard Moreau
Bernard Fromenty
Dominique Pessayre

Both acute and chronic alcohol consumption increase reactive oxygen species (ROS) formation and lipid peroxidation, whose products damage hepatic mitochondrial DNA (mtDNA). To test whether manganese s

Keywords:

General surgery
Glutathione
Oxidative stress
Mitochondrial DNA
Alcohol
Reactive oxygen species
Lipid peroxidation
Medicine
Internal medicine
Endocrinology
Biochemistry
Mitochondrion
Uric acid
Diabetes mellitus
alcohol consumption

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