The relationship between serum matrix metallopeptidase 9, metallopeptidase inhibitor 1, adiponectin and albuminuria in hypertension patients

Objective To explore serum levels of matrix metalloproteinase-9 (MMP-9),metallopeptidase inhibitor-1 (TIMP-1) and adiponectin (ADPN) and their correlation with albuminuria in hypertension patients.Methods A total of 175 adults who had health check-up in our center were enrolled in this investigation.All the subjects were tested for blood pressure,urinary albumin/creatinine ratio (ACR),fasting glucose,lipoprotein and serum creatinine.The subjects were then assigned to the normal control,albuminuria,hypertension,hypertension + albuminuria group,and serum MMP-9,TIMP-1 and ADPN were measured.Studnet's t test was used for data anlysis.Results The serum levels of MMP-9 and TIMP-1 in hypertensive patients were significantly higher than those of the normal controls (P ＜ 0.05 or P ＜0.01).Serum MMP-9 in hypertension + albuminuria group was higher than that of the hypertension group (P＜ 0.05).ADPN was significantly lower in hypertension + albuminuria group (P ＜ 0.05).Conclusion Serum MMP-9 and TIMP-1 may be in significantly increased in hypertensive patients.The balance of MMP-9/TIMP-1 and serum ADPN could be involved in the pathogenesis of albuminuria in patients with hypertension. Key words: Hypertension;  Matrix metalloproteinase-9;  Metallopeptidase inhibitor-1 ; Adiponectin