Effect of aldosterone antagonists on obstructive sleep apnea in patients with resistant hypertension: a systematic review and meta-analysis

We read an article written by Wolley et al.1 with interest. We found that treatment of primary aldosteronism by adrenalectomy or aldosterone antagonists was associated with a reduction in the severity of obstructive sleep apnoea (OSA). Although resistant hypertension (RH) is highly prevalent in patients with OSA and hyperaldosteronism, the authors did not recruit participants with RH. We completed a meta-analysis to assess the effect of aldosterone antagonists on OSA in patients with RH.