VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease
2019
Introduction
Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may contribute to the pathogenesis of Inflammatory Bowel Disease (IBD). VPR-254 is a selective in vitro inhibitor of RORγT.
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