Treatment of Edema and Increased Capillary Filtration in Venous Hypertension with HR (Paroven, Venoruton; 0-(β-hydroxyethyl)-rutosides): A Clinical, Prospective, Placebo-Controlled, Randomized, Dose-Ranging Trial

The variation of capillary filtration rate (CFR) and ankle edema (AE) were evaluated in three groups of patients with venous hypertension with ambulatory venous pressure > 42 mmHg and in healthy subjects before and after treatment for four weeks with HR (Paroven, Venoruton; 0-(P-hydroxyethyl)-rutosides), a venoactive drug acting on the microcirculation and on capillary permeability. Group A (30 patients) was treated with HR 500 mg tid; group B (30 patients) was treated with 1 g tid; group C (30 patients) was treated with placebo; group D (10 healthy subjects) was treated with HR 1 g/day in a randomised study. CFR was assessed by venous occlusion plethysmography. Subjective symptoms of venous hypertension were assessed by an analogue scale line considering four symptoms: swelling sensation, restless lower extremity, pain and cramps, and tiredness.Results: There were no significant differences for sex and age distribution among the groups; no significant differences were found for ambulatory venous pressure...