Anemia in Diabetes and Pre-Diabetes with Normal Kidney Function: Prevalence and Clinical Outcomes.

Abstract Objective Anemia is a known complication of diabetes mellitus (DM); however, its prevalence and prognostic relevance in patients with DM and pre-DM with normal kidney function is not well-defined. This study assessed the prevalence of anemia in DM and pre-DM patients and evaluated its association with clinical outcomes during 4-years’ follow-up. Methods This retrospective analysis included patients with DM and pre-DM referred to the Meir Medical Center Endocrine Institute during 2015. Patients with estimated glomerular filtration rate (eGFR) Results A total of 622 patients (408 with DM and 214 with pre-DM) were included. Mean age was 64±10.6 years, and 70% were women. Baseline HbA1c was 7.1±1.7% and eGFR was 86.1±15.3 ml/min. At inclusion 77 (19%) patients with DM and 23 (11%) with pre-DM, had anemia (hemoglobin 11.9±0.8 and 11.8±0.8 g/dl, respectively) vs. normal hemoglobin levels of 13.8±0.9 and 13.7±0.9 g/dl, respectively in the others. Multivariable analysis demonstrated an inverse correlation between baseline hemoglobin (as a continuous variable) and mortality (P=0.035), microvascular complications (P=0.003) and eGFR decline (P Conclusion This study found a significant prevalence of anemia unrelated to renal failure, both in DM and pre-DM. Anemia in these patients is associated with development of microvascular complications, eGFR decline and mortality. These results underscore the need for intensive lifestyle and pharmacological interventions among these patients.