Abstract 17229: First Trimester Elevated Serum Glucose Values Are Associated With Congenital Heart Disease in the Offspring

Introduction: Maternal diabetes mellitus (DM) during pregnancy is a well known and prevalent risk factor for congenital heart disease (CHD) in offspring. In mothers without DM, we recently observed an association between elevated serum glucose values measured in the second trimester and the risk for CHDs in offspring. Hypothesis: As cardiac development largely occurs during weeks 4-12 of gestation, we hypothesized that measurements of glucose metabolism during early pregnancy, i.e., well before the second trimester, would be associated with risk for CHD. Methods: We performed a multi-institutional retrospective case-control study from a population-based cohort of 19,107 pregnant women from Stanford Healthcare and Geisinger Health System comparing liveborn infants with CHD to infants without CHD (Table 1). Multivariable logistic regression analysis was used to investigate the association between 1) mother’s plasma glucose values from 4 weeks prior to conception to 15 weeks and 2) the 1hour glucose toleranc...