A Study of Infective Etiology in Patients With Acute Exacerbation of COPD

Introduction: An AE COPD is an acute event characterized by a worsening of the patient’s respiratory symptoms that is beyond normal day-to-day variations and leads to a change in medication. The most frequent bacterium isolated in all series was H. influenzae followed by Streptococcus pneumonia, Moraxella catarrhalis, Pseudomonas aeruginosa. The aim of this prospective study is to assess the bacterial etiology related to acute exacerbation COPD from culture and sensitivity. Aim and Objectives: To study sputum microbiological profile in patients admitted with acute exacerbation COPD. Materials and Method: Prospective Observational Study. The study population consisted of patients with AE of COPD were checked for sputum culture. Depending upon the isolation of bacteria antibiotic sensitivity patients were treated accordingly. Results: This study presented here involved 200 patients with history of AECOPD. Total 50.00% of patients had Gram Negative Bacilli infection & 22.00% patients had Gram Positive Coci infection & in 28.00% patients no organisms were isolated. 32% cases were found to be infected with Pseudomonas species, 12% of streptococcus Pneumonie, in 6% Streptococcus Pyogens, 8% kleibsiella Pneumoniae, 4% E.coli, 6% H. Influenza. Organisms were most commonly sensitive to pipericillin&tazobactum, Amikacin, Azithromycin, ciprofloxacin. Conclusion: AECOPD have a major impact on the quality of life. They are a major cause of hospital admission and health care utilization. Pseudomonas species was the commonest. If done well, it can replace the costlier diagnostic methods like Immunodiffusion. Also antibiogram can help in effective treatment.