Early use of ulinastatin reduces Multiorgan Dysfunction (MODS) in septic shock following anastomotic failure

e112 Volume 37 Number 8S Bishkek Kyrgyzstan; Ministry of Health, Bishkek Kyrgyzstan; and Kyrgyz-Russian Slavic University Introduction: Well-known that the medicines safety issues has been required increasing attention worldwide. As for Kyrgyzstan pharmacovigilance has been established since 2002 only. Well organized pharmacovigilance system is the base for rational and safely use of medicines and more over is the base for optimization of health facility’s operation. Objective of this work is to evaluation of frequency and severity of adverse drug reactions (ADRs) and highlighting the importance of medicines safety issues in health system. Methods: Spontaneous reporting method and retrospective analysis of medical cards of hospital patients have been used. Statistical analysis has been done by MS Excel 2010. Results: A total of 11,630 medical cards of patients in 10 hospitals of country were analyzed; only 5 cases of ADR were registered, that is the proof of apparent lack of doctor’s activities on that direction. From our view it is due to the low awareness of majority medical professionals on the need to informing about ADR (91%). Also, another reason of low registration of ADRs is the limited knowledge on recognition the events associated with use of medicines (72%). It must be noted that the active implementation of pharmacovigilance has been initiated since 2013. Out of total 666 reports have been received from the period of 2002 to 2014, 30% have been received in 2013-2014. The main parts of ADRs were due to use of antibiotics (37%), anti-TB drugs (10.5%), vaccines (10.3%). 40.4% of reports due to use of injection medicines. Conclusion: The current situation of pharmacovigilance is not fully effective, so by nowadays there is no reliable statistical data on ADRs. The situation on pharmacovigilance has been improving since 2013 as a result of organizational and educational activities held, that is proving there is a need of further more focused and regular activities at all levels of health care system.