Study on Improving Insulin Resistance with LBP-4a in Diabetes Mellitus Rats

The experiment mean to explore the improving insulin resistance(IR) mechanism of Lycium barbarum polysaccharide-4a(LBP-4a) in non-insulin dependent diabetes mellitus(NIDDM) rats.LBP was extracted from Ningxia-Lycium barbarum by water extraction and ethanol precipitation technique.And the ingredient of LBP-4a was obtained by separation and purification.The animal model of NIDDM was made by feeding high-glucose and high-fat diet and subjecting to.i.p.little-dose streptozotocin(STZ).The rats of NIDDM model were divided into four groups,including model group,LBP-4a low-dose and high-dose groups,rosiglitazone group and normal control group.In order to research the effect of LBP-4a on reducing blood glucose and ameliorating IR in NIDDM rats,a lot of techniques were used such as Single Cell Gel Electrophoresis et al.We studied systematically the effect of LBP-4a on IR in NIDDM rats and researched the mechanism.The results indicated that LBP-4a had lipid-lowering effects on NIDDM rats.Furthermore,LBP-4a had antioxidative function and repairing DNA damage on NIDDM rats.Therefore,LBP-4a as a dietary supplement may improve IR and prevent the development of complications or even tendency to carcinogenesis in NIDDM rats.