A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly

Objective To observe the efficacy,toxicity and side effects of vinorelbine monotherapy in the treatment of advanced non-small cell lung cancer in the elderly.Method Twenty-one elder patients with advanced non-small cell lung cancer were treated with vinorelbine.The efficacy was estimated after 2 cycles.Results Complete remisson(CR) was observed in 1 case,PR in 5 cases and SD in 6 cases,the response rate,time to progress(TTP),median survival time(MST) and 1-year survival rate were 28.6%,5.1 months,7.2 months and 30.1% respectively.The toxicity and side effects were leucopenia and thrombocytopenia,but they were tolerable.Conclusion Vinorelbine monotherapy in the treatment of the elderly with advanced non-small cell lung cancer is effective,safe and well tolerable.It can relieve the symptoms,improve quality of life and prolong the survival time.Elder patients were willing to receive it.