Abstract 11877: Beta-blocker Dose Stratifies Both Mortality Risk and Circulating Procollagen Levels In African-Americans With Heart Failure

Introduction: While African Americans (AAs) have the highest prevalence of heart failure (HF) and HF mortality, insufficient data exists regarding the impact of HF medication on mortality in AAs. This study aimed to identify medication use practices associated with survival in a predominantly AA HF population. Methods: HF patients were prospectively recruited from, and followed within, the University of Illinois Health System from 11/2001 to 11/2015, when vital status was determined. Data were extracted from electronic health records and Social Security Death Index. Beta-blocker (BB), ACE-I, and ARB doses were categorized as high, medium, or low based on published HF trials. Associations between dose and all-cause mortality were assessed using a Cox proportional hazard model, adjusting for enrollment age, sex, race, ischemic or non-ischemic etiology, NYHA functional class, and concomitant HF medication use. Using linear regression (adjusted for the same covariates), doses were also compared with plasma pr...