Development of novel antibacterial gel using clove and calendula extracts with colloidal silver nanoparticles

This study focuses on obtaining an extract from clove and calendula plants with colloidal nanoparticles of silver in the presence of 40% propyleneglycol and preparation of hydrophilic gel based on the resulting extract. Also, the optimal composition of the gel and releasing of biologically active substances from gels based on chitosan, sodium carboxymethylcellulose, carbopol, used as gelling agents was evaluated. The results showed that the release of bioactive compounds from a chitosan-based gel is more complete and intensive. The antibacterial and antifungal properties of chitosan gel containing silver nanoparticles have been confirmed by microbiological studies.