Quelle leçon tirer de l'inefficacité des inhibiteurs du système rénine-angiotensine dans la prévention primaire de la néphropathie diabétique?

The results of the Renin Angiotensin System Study show the inefficiency of inhibitors of the renin angiotensin system in primary prevention of the renal disease associated with type 1 diabetes. The complexity of the renin angiotensin system, the limited therapeutic efficiency of its inhibitors and chronic hyperglycaemia are the likely major reasons of these negative results. Utilization of renin inhibitors could be an alternative.