017 One year outcome in HIV-infected patients with myocardial infarction. Analysis from a French nationwide hospital medical information database

Results: On-treatment platelet reactivity with clopidogrel 75mg, 150mg or prasugrel 10mg was always higher in elderly patients (n=197) than in younger patients (n=1074) whatever the test used. The difference in PRU in response to ADP-PGE1 agonist between the two populations was +45; p<0.0001 in patients treated with clopidogrel 75mg, +30; p=0.17 in patients treated with clopidogrel 150mg and +20; p=0.08 with prasugrel 10mg. Elderly patients displayed a higher rate of HPR on clopidogrel 75mg than younger patients (38.2% vs. 18.2%; p<0.0001) (figure) and a lower rate of HPI (2.3% vs. 8.7%; p=0.01). Of note, diabetes and the distribution of the genotype for the loss of function allele 2C19*2 were similar in both population and could not explain the higher rate of HPR of the elderly.