A prospective appraisal of pulmonary hypertension in children with sickle cell disease.

ObjectivesPulmonary hypertension (PHT) is a life-threatening complication of sickle cell disease that occurs in 20% to 40% of adults. Measurement of maximal tricuspid regurgitant jet velocity (TRV) by echocardiography provides a noninvasive screening tool; TRV values ≥2.5 m/s are correlated with PHT