Additional file 9: of Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease

Linear discriminant analysis reveals sensitivity and selectivity of analytes in discriminating between HC and PD. Serum and CSF levels of IL-6 (a), serum IL-6 (b). Serum and CSF IL-8, TNF, NGAL, and IFNγ, and CSF α-synuclein, Aβ40 and Aβ42 (d), serum IL-8, TNF, NGAL, IFNγ, and CSF α-synuclein, Aβ40, and Aβ42 (e), serum and CSF IL-8, TNF, NGAL, IFNγ, and CSF Aβ40 (f), serum and CSF IL-8, TNF, NGAL, IFNγ, and CSF Aβ42 (g), serum and CSF IL-8, TNF, NGAL, IFNγ, and CSF α-synuclein (h), serum and CSF IL-8, TNF, NGAL, IFNγ (i), serum IL-8, TNF, NGAL, IFNγ, and CSF Aβ42 (j), serum IL-8, TNF, NGAL, IFNγ, and CSF α-synuclein (k), serum IL-8, TNF, NGAL, IFNγ, and CSF Aβ40 (l), serum and CSF TNF, NGAL, IFNγ, and CSF α-synuclein, Aβ40, and Aβ42 (m), serum TNF, NGAL, IFNγ, and CSF α-synuclein, and Aβ42 (n), serum TNF, NGAL, and IFNγ (o), serum and CSF TNF, NGAL, and IFNγ (p), serum TNF, NGAL, and IFNγ and CSF α-synuclein, Aβ40, and Aβ42 (q), serum TNF and CSF α-synuclein, and Aβ42 (r), serum TNF and CSF Aβ42 (s), serum IL-8, TNF, NGAL, and IFNγ (t). The x axis is the percentage of correct categorization into a group, and the red line is set at the lowest percentage of correct categorizations for the factor or factors considered. The y axis is the collection hour. (PDF 239 kb)