Hemodynamic effects of the vasodilation in different vascular regions on patients with severe left ventricle systolic dysfunction

Objective. To determine the specificity of the vasodilation of isosorbide dinitrate (ID), nitric oxide (NO), inhaled iloprost (iIlo). Materials and methods. Study included 190 vasoreactivity tests (ID, NO or iIlo, Swan-Ganz catheter) performed in 124 candidates for heart transplantation. Results. In the ID group mean PAP decreased by 22.8±14.7 %, in the NO - by 5.9±17.4 %, in the iIlo - by 14.6±15 %, PAWP in the ID group decreased by 29±17 %, in the iIlo - by 3.9±27.2 %, but in NO PAWP increased by 11±33.7 %. When using NO, SVI decreased from 23.8±7.9 to 22.4±6.7 ml/m 2 . When using D, SVI increased by 29.2±27.7 %, as well as in the iIlo by 20.6±24.5 %. Conclusion. Selective vasodilation of pulmonary vessels by NO caused LV overload and a decrease in LV output.